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In Vitro ADME

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MDS Pharma Services technical directors developed a two tier system for in vitro ADME to assist our clients in designing a testing strategy that saves time and expense. Discovery level testing can be done rapidly in a higher throughput model. Development level testing, which requires more expertise and careful planning, is conducted in our labs by experienced staff according to the regulatory requirements for drug registration.

Discovery ADME assays deliver the basic and critical information to allow researchers to rank order their compounds according to physiochemical, metabolic, and CYP inhibition properties. Researchers use our data to identify compounds that exhibit desirable ADME properties for their intended therapeutic target.

Development ADME tests are designed to provide more detailed answers for compounds that were pre-screened in our discovery ADME assays and have initial CYP interaction, inhibition, and some basic solubility data. These assays are more detailed with more custom options than our discovery set.

MDS Pharma Services offers a broad range of in vitro ADME services to assist pharmaceutical and biotechnology companies in candidate selection. These services include:

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Click on appropriate assay name for additional assay information. Click on any column header to sort list by that column.
Catalog #▲  Assay NameFamily Name
710050 CYP450 ID Part 1 of 5 - rCYP Phenotyping Development In Vitro ADME
710060 CYP450 ID Part 2 of 5 - Metabolic Stability Protein Time Array Development In Vitro ADME
710070 CYP450 ID Part 3 of 5 - Correlation Analysis Development In Vitro ADME
710080 CYP450 ID Part 4 of 5 - Confirmation Development In Vitro ADME
710090 CYP450 ID Part 5 of 5 - Enzyme Kinetics & Solubility Development In Vitro ADME
710020 CYP450 Inhibition 5 in 1 Discovery In Vitro ADME
710120 CYP450 Inhibition IC50 Development In Vitro ADME
710110 CYP450 Inhibition KI and Mechanism of Inhibition Development In Vitro ADME
710100 CYP450 Inhibition Panel Screen Development In Vitro ADME
710010 LogD7.4 Discovery In Vitro ADME
710040 Metabolic Soft Spot Analysis Discovery In Vitro ADME
710150 Metabolic Soft Spot Analysis - Microsomes or Hepatocytes Development In Vitro ADME
710000 Metabolic Stability Discovery In Vitro ADME
710130 Metabolic Stability - Hepatocytes Development In Vitro ADME
710140 Metabolic Stability - Microsomes or S9 - ClINT Development In Vitro ADME
710160 Quantitative Solubility Measurement