ImmunoSIGNAL™ TCR is a cytokine release assay designed to evaluate T-Cell activation in response to anti-CD3 and anti-CD28 antibody co-stimulation in Jurkat cells or PBMC. TCR activation plays a lead role in immune response.
The ImmunoSIGNAL™ TCR Advantage
- Inflammatory disease model provides the ability to characterize modulation of inflammatory ctyokine IL-2 in Jurkats.
- Assay parameters validated for sensitivity, robustness and characterization of cytokine level
- Induction by co-stimulation with anti-CD3 and anti-CD28 antibody
Service Features
- EC50 or single concentration formats
- Compounds tested in duplicate or triplicate
- Data provided as percent of control and pg/mL for each cytokine
- Concurrent Alamar Blue toxicity screen
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960150
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anti-CD3, anti-CD28
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