Client-Specific Assay Package
MDS Pharma Services works closely with select clients to develop and implement client-specific custom screening programs. Most often these programs are designed by clients to profile and further characterize the pharmacological specifity and selectivity of leads or hits emerging from internal discovery programs.
The information provided by these customized programs is used to help guide: 1) selection of leads to be further studied; 2) optimization of Structure Activity Relationships (SARs); and 3) detection of secondary pharmacology effects to be further evaluated.
These client-specific custom screening packages have proven valuable to research and development committees as well as management. They provide a consistent body of data on leads emerging from screening activities and being considered for further development.
Inclusion Of Proprietary Assays
As an integral part of a client-specific custom screen, in-house proprietary assays, which the company wishes to use but not maintain on a routine basis in their own laboratories, may be transferred to our labs and used only on samples submitted by the client.
Any mix of assays available from MDS Pharma Services (enzyme, radioligand binding, cellular, tissue, in vivo, anti-infective, or tumor) may be included. We can usually include and automatically conduct secondary functional assays as part of a client-specific custom screen to provide more relevant and complete pharmacological information.
Typical Program Format
Standard procedures include initial screening in duplicate and confirmation tests at the same concentration. For tests indicating significant activity, MDS Pharma Services will conduct semi-quantitative dose responses at 10-fold, 100-fold, and 1000-fold lower concentrations as well as appropriate secondary testing.
Secondary tests are run at a high initial concentration, with minimal inhibitory concentration (MIC) or minimal effective dose (MED) determinations to access possible agonist or antagonist activity. Concurrent vehicle and reference standards are run with each assay. The amount of sample required is dependent on which assays are included in the client’s screening package.
How To Initiate A Client-Specific Custom Screen
Simply contact MDS Pharma Services. We will work with you to develop and implement your individual program. Pricing incentives may apply to your program, relative to its overall scope.
Customized hard-copy and electronic data report formatting requirements can be accommodated.
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