Our accelerated throughput cytotoxicity mechanism of action assay utilizes automated cell image acquisition and analysis technology to obtain simultaneous cellular cytotoxic mechanism data, High Content Cellular Assays.
Nuclei are shown in blue. Activated Caspase 3 is in green. Mitotic cells are labeled in red.
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MDS Pharma Services Advantage
- Access to automated, robust, state-of-the-art technology that maximizes data per assay well by measuring cell proliferation, apoptosis and cell cycle
- Accelerated throughput screening (900 compounds per week)
- Objective, consistent and fast
- Experience with more than 300 human cell lines
Service Features
- Compound testing in pre-validated human cell lines: CHO-K1, HepG2, HUVEC, HeLa or HCT-116 cells
- Apoptotic marker - activated Caspase 3
- Proliferation assay - relative cell count
- Cell cycle analysis - Phospho-Histone 3 marker of mitotic cells
- Necrosis (cell membrane permeability marker) – 7-Amino-actinomycin D or Propidium Iodide (Optional)
- Minimum compound requirements (2-3 mg) due to 384 well plate formats and non-contact acoustic energy based compound addition
- A reference compound included as a control on each plate
- 4 week turnaround time
Contact Us
for additional Safety testing information.
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