Cardiac Safety Assays

Cardiac Safety Ion Channel Testing Services

Cardiac Safety Assays

Patch Clamp Functional Assays
Automated Patch Clamp Electrophysiology uses the state-of-the art PatchXpress® 7000 platform to provide higher-throughput gold-standard patch clamp electrophysiology data. Now we offer the assurance of accurate functional data scaled to meet the needs of discovery phase R&D.

Automated Patch-Clamp Q&A | Request a Poster | Download Presentation

Ion Channel Service
Functional hERG
Functional hNav1.5
Functional hCav1.2

GLP Electrophysiology Recordings
These IND enabling GLP studies are offered as a follow up to the functional ion channel assays for compounds moving forward in the development pipeline.

Ion Channel Service
GLP-hERG Testing

Binding Assays
For nonfunctional but fast screening the radioligand binding assays were developed to identify compounds which may have inhibitory effect on electrophysiology activity and potential cardiotoxicity in a cost-effective way.

Technical Q&A

Catalog #	▲ Assay Name	Species	Price
214600	Calcium Channel L-Type, Dihydropyridine	Rat	$37
265900	Potassium Channel hERG	Human	$62
279510	Sodium Channel, Site 2	Rat	$49

Tissue Assays
In vitro tissue pharmacology assays may serve to extend results obtained from radioligand binding or enzyme assays to identify compounds which may have inhibitory effects on electrophysiology activity and potential cardiotoxicity as well as direct potentially important primary or secondary functional biological activities.

Catalog #	▲ Assay Name	Species	Price
415000	Calcium Channel L-Type, Atrial Inotropy	Guinea pig	$182
415510	Calcium Channel L-Type, Ileum	Guinea pig	$137
475010	Sodium Channel, Site 2	Guinea pig	$227

In Vivo QTc Prolongation Assay
This in vivo assay has sensitivity for detecting effect of hERG inhibitors on QTc interval; it is especially useful in candidate selection. This model uses hERG channels for ventricular repolarization, cardiac electrophysiology similar to humans.

Catalog #	▲ Assay Name	Species	Price
516350	Cardiovascular, QTc Interval	Guinea pig	$486