The TRP family contains more than 28 members with diverse modes of activation. TRP subfamilies include classical (TRPC), vanilloid receptors (TRPV), melastatin (TRPM), polycystins (TRPP), mucolipins (TRPML), and ankyrin transmembrane protein 1 (TRPA). Some TRP channels are voltage-gated, though not strongly so, with others sensitive to intracellular Ca2+, pH, redox state, osmolarity, and mechanical stretch.
Binding Assays
For nonfunctional but fast screening the radioligand binding assays were developed to identify compounds which may interact with electrophysiology activity in a cost-effective way.
Tissue Assays
In vitro tissue pharmacology assays may serve to extend results obtained from radioligand binding or enzyme assays as well as detect potentially important primary and/or secondary functional biological activities.
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480000
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Vanilloid
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Rat
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$272
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