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Voltage-Gated Ion Channels

The voltage-gated channel family includes Na+, Ca2+ and K+ channels whose open and closed states are mediated by changes in cell membrane potential. These multimeric channels tightly regulate the flux of ions across cell membranes and maintain ionic gradients required for normal cell function including but not limited to, neurons, skeletal and cardiac muscle cells.

Patch Clamp Functional Assays
Automated Patch Clamp Electrophysiology uses the state-of-the art PatchXpress® 7000 platform to provide higher-throughput gold-standard patch clamp electrophysiology data. Now we offer the assurance of accurate functional data scaled to meet the needs of discovery phase R&D.

Ion Channel Service
Functional hKv1.3

Binding Assays
For nonfunctional but fast screening the radioligand binding assays were developed to identify compounds which may interact with electrophysiology activity in a cost-effective way.

Catalog #▲  Assay NameSpeciesPrice
214510 Calcium Channel L-Type, Benzothiazepine Rat $37
214600 Calcium Channel L-Type, Dihydropyridine Rat $37
215000 Calcium Channel L-Type, Phenylalkylamine Rat $37
216000 Calcium Channel N-Type Rat $44
265500 Potassium Channel [KA] - Temp. Unavailable Rat $41
265600 Potassium Channel [KATP] Hamster $37
265900 Potassium Channel hERG Human $62
279510 Sodium Channel, Site 2 Rat $49

Tissue Assays
In vitro tissue pharmacology assays may serve to extend results obtained from radioligand binding or enzyme assays as well as detect potentially important primary and/or secondary functional biological activities.

Catalog #▲  Assay NameSpeciesPrice
464500 Portal Vein, Potassium Depolarized Rat $182
466100 Potassium Channel [KATP] Rat $182
475010 Sodium Channel, Site 2 Guinea pig $227

In Vivo Assays
In vivo pharmacology assays may serve to extend in vitro results or detect potentially important primary and/or secondary pharmacodynamic activities.

Catalog #▲  Assay NameSpeciesPrice
505500 Analgesia, Phenylquinone (PQ) Writhing, Safety non-GLP Mouse $147
505700 Analgesia, Post-operative Pain Rat $385
506020 Analgesia, Tail Flick Mouse $147
506040 Analgesia, Tail Flick Rat $188
506500 Analgesia, Tail Flick, Safety non-GLP Mouse $147
508010 Anesthesia, Local, 5, 15, 30, 60 min Guinea pig $188
512010 Cardiac Arrhythmia, Aconitine Mouse $147
512060 Cardiac Arrhythmia, Aconitine Rat $244
516350 Cardiovascular, QTc Interval Guinea pig $486
568020 Potassium Channel [KATP] Agonism/Antagonism Mouse $147